In an article, author is Soler, Lucia, once mentioned the application of 495-40-9, Name: 1-Phenylbutan-1-one, Name is 1-Phenylbutan-1-one, molecular formula is C10H12O, molecular weight is 148.2, MDL number is MFCD00009397, category is isothiazole. Now introduce a scientific discovery about this category.
Synthesis of omega-(1,1,3-trioxo-1,3-dihydrobenzo[d] isothiazol-2-yl)-alkanecarboxylic acids: conventional versus microwave heating
The alkylation of sodium saccharin with alkyl halides to produce the intermediates.-( 1,1,3-trioxo-1,3-dihydrobenzo[d]isothiazol-2-yl)-alkanecarboxylic acids can be markedly improved by using microwave irradiation, both in terms of product yield and reaction time. While the process produces high yields with halo esters and halonitriles, the reaction with haloacids, which proceeds smoothly by conventional reflux, gives poorer yields with microwaves. This is due to an acid-base equilibrium produced by the rapid heating of the mixture under irradiation. Esters and nitriles can be converted into the acids by acid hydrolysis, without appreciable loss of the 1,1,3-trioxo-1,3-dihydrobenzo[ d] isothiazole ring.
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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com