936-16-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, cas is 936-16-3,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.
2-Chloro-4-(4-Boc-piperazin-l-yl)quinazoline (140 mg, 0.40 mmol), 253-dihydro-l,2- benzisothiazole l5l-dioxide (85 mg, 0.50 mmol) and potassium carbonate (110 mg, 0.80 mmol) in DMSO (2 ml) were heated at 90¡ã for 16 h and then at 110¡ã for 5 h. The reaction mixture was diluted with brine and extracted with dichloromethane (x3). The combined o organic phases were dried (MgSO4) and evaporated to dryness. The residue was dissolved in dichloromethane (2 ml) and TFA (0.5 ml) was added. The reaction mixture was stirred at ambient temperature for 16 h. The solvent was evaporated and the crude was purified by preparative HPLC to give the acetate of the title compound (71 mg, 40percent). 1H NMR (400 MHz, DMSO-J6) d ppm 7.90 – 8.02 (2 H, m) 7.61 – 7.84 (5 H, m) 7.33 – 7.41 (1 H3 m) 5.19 (2 H, s) 3.79 – 3.88 (4 H, m) 2.87 – 2.95 (4 H, m); ESI-MS m/z M+H+ 382.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, 936-16-3
Reference£º
Patent; ASTRAZENECA AB; WO2007/108744; (2007); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com