18480-53-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.
(3,4-dichloroisothiazol-5-yl)methanolA solution of 3,4-dichloroisothiazole-5-carboxylic acid (2.0 g), N1N- dimethylformamide (few drops) and thionyl chloride (20 mL) in toluene (60 mL) was heated at 1000C for 16 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in tetrahydrofuran (20 mL), cooled to -200C under a nitrogen atmosphere and treated dropwise with a 1.0 M sodium borohydride solution in N, N- dimethylformamide (8.5 ml.) over 1 hour. The mixture was stirred for 5 minutes after the end of addition and quenched with 1.0 M aqueous hydrochloric acid solution. The mixture was concentrated to low bulk under reduced pressure and extracted with ethyl acetate. The combined organic layer was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with a mixture of cyclohexane and dichloromethane (1 :0 to 0:1 by volume), to afford the title compound as a pale yellow solid (1.1 g).1H NMR (300 MHz, CDCI3): delta 2.60 (s, 1H); 4.96 (s, 2H).
The chemical industry reduces the impact on the environment during synthesis,18480-53-0,3,4-Dichloroisothiazole-5-carboxylic acid,I believe this compound will play a more active role in future production and life.
Reference£º
Patent; PULMAGEN THERAPEUTICS (ASTHMA) LIMITED; HYND, George; MONTANA, John Gary; FINCH, Harry; ARIENZO, Rosa; AHMED, Shahadat; WO2010/142934; (2010); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com