10271-85-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Isothiazole-5-carboxylic acid, cas is 10271-85-9,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution isothiazole-5-carboxylic acid 46 (1.75 g, 13.56 mmol) in CH2Cl2 (50 mL) under inert atmosphere were added N, O-dimethylhydroxylamine (1.45 g, 14.92 mmol), EDCI.HCl (2.85 g, 14.92 mmol), DMAP (1.66 g, 13.56 mmol) and N-methylmorpholine (4.1 mL, 40.69 mmol) at 0 oC, followed by warming to room temperature and stirring for 16 h. The reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured into ice-cold water, extracted with CH2Cl2. The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain the crude. The crude was purified through silica gel column chromatography using 2% MeOH/ CH2Cl2 to afford compound 47 (1.2 g, 52%) as brown syrup. TLC: 5% MeOH/ CH2Cl2 (Rf: 0.2); 1H NMR (400 MHz, DMSO-d6): delta 8.64 (d, J = 1.8 Hz, 1H), 7.96 (d, J = 1.8 Hz, 1H), 3.82 (s, 3H), 3.33 (s, 3H); LCMS Calculated for C6H8N2O2S: 172.03; Observed: 173.1 (M+1)+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Isothiazole-5-carboxylic acid, 10271-85-9
Reference£º
Patent; ASSEMBLY BIOSCIENCES, INC.; TURNER, William, W., Jr.; LI, Leping; HAYDAR, Simon, Nicolas; BURES, Mark, G.; RAI, Roopa; FRANCIS, Samson; ARNOLD, Lee, Daniel; (0 pag.)WO2018/160878; (2018); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com