Analyzing the synthesis route of 18480-53-0

18480-53-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,18480-53-0 ,3,4-Dichloroisothiazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3,4-Dichloroisothiazole-5-carboxylic acid, and cas is 18480-53-0, its synthesis route is as follows.

In a 250 ml round bottom flask in water are sequentially added methanol 80 ml, 3,4-dichloro-thiazole-5-carboxylic acid (10.7 g, 53.8 mmol), gradually under the condition ice bath adds by drops two chlorine Asia sulphone (9.6 g, 80.7 mmol), the drop finishes heated to 40 degree c stirring 5 hours, after the reaction is complete to concentrate, add ethyl acetate to dissolve the filter, the filtrate of the distilled water are used to, saturated NaHCO3saturated NaCl wash again, anhydrous magnesium sulphate dried, concentrated, vacuum drying the white solid obtained 11.2 g, yield 98percent

18480-53-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,18480-53-0 ,3,4-Dichloroisothiazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Nankai University; Fan, Zi Jin; Zong, guangning; Li, Feng Yun; Li, yuedong; Li, Juan Juan; Ji, xiaotian; Chen, Lai; Zhu, Yu Jie; Liu, chaolun; Cheng, shengming; (21 pag.)CN103497182; (2016); B;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com