Application of 87691-88-1, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Application of 87691-88-1, name is 3-Piperazinobenzisothiazole hydrochloride, introducing its new discovery.
Orally-effective, long-acting sorbitol dehydrogenase inhibitors: Synthesis, structure – Activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines
Optimization of a previously disclosed sorbitol dehydrogenase inhibitor (SDI, II) for potency and duration of action was achieved by replacing the metabolically labile N,N-dimethylsulfamoyl group with a variety of heterocycles. Specifically, this effort led to a series of novel, in vitro potent SDIs with longer serum half-lives and acceptable in vivo activity in acutely diabetic rats (e.g., 62, 67, and 69). However, the desired in vivo potency in chronically diabetic rats, ED90 ? 5 mg/kg/day, was achieved only through further modification of the piperazine linker. Several members of this family, including 86, showed better than the targeted potency with ED90 values of 1-2 mg/kg/day. Compound 86 was further profiled and found to be a selective inhibitor of sorbitol dehydrogenase, with excellent pharmacodynamic/pharmacokinetic properties, demonstrating normalization of sciatic nerve fructose in a chronically diabetic rat model for ?17 h, when administered orally at a single dose of 2 mg/kg/day.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application of 87691-88-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 87691-88-1, in my other articles.
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com