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Synthesis, characterization and antibacterial activity of 3-(2-(Heterocyclo-2-ylthio)-ethoxy)benzo[d]isothiazoles(1)

Seven novel 3-(2-(heterocyclo-2-ylthio)ethoxy)benzo[d]isothiazoles (3a?3g) have been synthesized and characterized by ESI-MS and 1H and 13C NMR spectra. The crystal structures of 3a and 3g have been determined. Compound 3a (C11H11N5O1S2) belongs to the monoclinic system and 3g (C12H11N3OS3) to the triclinic system. The title compounds show excellent in vitroantibacterial activities, with the minimum inhibitory concentrations varying from 4 to 32 ug/mL.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com