Electric Literature of 272-16-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.272-16-2, Name is Benzo[d]isothiazole, molecular formula is C7H5NS. In a Article£¬once mentioned of 272-16-2
Design, synthesis and evaluation of phenethylaminoheterocycles as Kv1.5 inhibitors
Phenethylaminoheterocycles have been prepared and assayed for inhibition of the Kv1.5 potassium ion channel as a potential approach to the treatment of atrial fibrillation. A diverse set of heterocycles were identified as potent Kv1.5 inhibitors and were advanced to pharmacodynamic evaluation based on selectivity and pharmacokinetic profile. Heterocycle optimization and template modification lead to the identification of compound 24 which demonstrated increased atrial effective refractory period in the rabbit pharmacodynamic model with mild effects on blood pressure and heart rate.
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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com