Properties and Exciting Facts About 107869-45-4

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Metal-Free Synthesis of the Methanol Solvate of (S)-Omeprazole Potassium Salt Using (1 R)-(-)-10-Camphorsulfonyloxaziridine: Oxidation Process Development and Optical Purity Enhancement Strategy

The results of our process development studies to synthesize the methanol solvate of (S)-omeprazole potassium salt (1) through the enantioselective oxidation of pyrmetazole (2) using (1R)-(-)-10-camphorsulfonyloxaziridine (3) are reported. Optical purity enhancement was achieved by means of a reslurry from methanol, the rationale and development details of which are also described.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

The important role of Isothiazole

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Shake-up transitions in the X-ray photoelectron spectra of some five-membered heterocycles containing two heteroatoms

Low energy, low intensity shake-up satellites are observed in the various energy regions of the XPS spectra of imidazole, pyrazole, thiazole, isothiazole and isooxazole.Their energy and intensity trends are the same as those previously observed for furan, thiophen and pyrrole and semiquantitatively reproduced by CNDO/S-CI calculations.They derive from ?-?* transitions of pseudo-b1 symmetry usually involving charge transfer away from the core-ionized atom towards adjacent atoms, often from the heteroatom X (X = O,S,NH) towards the ring.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Awesome and Easy Science Experiments about Isothiazole

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Carbene complexes derived from lithiated heterocycles, mainly azoles, by transmetallation

Heterocyclic carbene complex formation can be achieved by lithiation of CH-acidic azoles, transmetallation involving a variety of transition metal complexes and, finally, protonation or alkylation. This article describes the synthetic methodology involved with a special emphasis on unexpected or (presently) unusual features of the reactions or products. The procedure can be extended to allow carbene complex formation by reaction at remote heteroatoms and also for diorgano(carbene) complex formation. Certain azolyls do not substitute but add to coordinated carbonyls and the resulting anionic Fischer-type carbene complexes can function as bidentate ligands. With gold(I) as central metal, many azolyls as well as carbene complexes participate in homoleptic rearrangement.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Archives for Chemistry Experiments of 288-16-4

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METHODS AND COMPOSITIONS FOR AFFECTING THE FLAVOR AND AROMA PROFILE OF CONSUMABLES

This document relates to food products containing highly conjugated heterocyclic rings complexed to an iron ion and one or more flavor precursors, and using such food products to modulate the flavor and/or aroma profile of other foods. The food products described herein can be prepared in various ways and can be formulated to be free of animal products.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Some scientific research about 272-16-2

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Microwave-induced pyrolysis of waste truck tyres with carbonaceous susceptor for the production of diesel-like fuel

Microwave-induced pyrolysis technique was utilised to pyrolyse waste truck tyres (TT) into useful pyrolysis oil with the aid of activated carbon. The effect of temperature was studied to determine the truck-tyre pyrolysis oil (TTPO) yield, hydrocarbon fractions, chemicals composition, energy yield and fuel properties. The activated carbon functions as microwave absorber to elevate the pyrolysis temperature for enhancing production of pyrolysis oil. The optimal pyrolysis temperature of 500 C produces highest TTPO yield of 38.12 wt% with calorific value of 42.39 MJkg?1 and energy yield of 40.55 wt%. Detailed analysis shows the TTPO contained large amount of aromatic hydrocarbons and limonene (14.29%) compared to pyrolysis oil from personal car tyre. Among the important chemical compounds also discovered in TTPO are benzene, toluene, xylene (BTX). The relative yields of toluene obtained at 400 C is 14.85%, whereas the relative yields of benzene and xylene at 450 C were 0.85 and 7.60%, respectively. The physiochemical properties of TTPO500 are rather similar to conventional diesel, except the slightly lower flash point and calorific value for the former. This work shows that microwave-induced pyrolysis is a promising technique to recover diesel-like fuel for use as supplemental alternative fuel.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Discovery of Isothiazole

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A vascular endothelial growth factor inhibitor injection of the pharmaceutical composition (by machine translation)

The invention belongs to the field of medicine, in particular to inhibit VEGF salts of the compound of formula I of injection drug composition, in pharmaceutical use and pharmaceutical formulations, particularly with respect to the tumor, the treatment of angiogenesis. The invention also relates to the method for synthesizing the compounds. (by machine translation)

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

New explortion of Benzo[d]isothiazole

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Perspectives on the role of the frontier effective-for-reaction molecular orbital (FERMO) in the study of chemical reactivity: An updated review

Molecular orbitals are critical in the rationalization of several chemical reactions. Thus, the frontier molecular orbital theory, proposed by Fukui?s group, postulated the importance of the Highest Occupied Molecular Orbital (HOMO) and the Lowest Unoccupied Molecular Orbital (LUMO) for chemical reactions. It should be kept in mind, however, that there are limitations of this theory and new perspectives about the chemical reactivity have recently been arisen based on composition and location of other frontier molecular orbitals. In this review, we have reported the development and the most recent applications of the Frontier Effective-for-Reaction Molecular Orbital (FERMO) concept, which describes the breaking and formation of new chemical bonds and can in turn, provide important clues that modulate chemical reactivity of atoms and molecules.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

A new application about 18480-53-0

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5-FLUORO PYRIMIDINE DERIVATIVES

This present disclosure is related to the field of 5-fluoro pyrimidines and their derivatives and to the use of these compounds as fungicides.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Extended knowledge of Isothiazole-4-carboxylic acid

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Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, the author is and a compound is mentioned, Recommanded Product: 822-82-2, Isothiazole-4-carboxylic acid, introducing its new discovery. Recommanded Product: 822-82-2

BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ESTROGEN AGONISTS/ANTAGONISTS

This invention relates to compounds, in particular benzimidazoles, that are useful as estrogen agonists and/or antagonists and pharmaceutical uses thereof. The present invention also relates to benzimidazoles that are selective for the ERss receptor and pharmaceutical uses thereof.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Awesome Chemistry Experiments For 288-16-4

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Coordination chemistry of thiazoles, isothiazoles and thiadiazoles

Thiazole derived compounds have great potential in medicinal- and agro-chemistries, catalysis, cosmetic industry, corrosion protection, light harvesting, production of light-emitting diodes (LEDs), photochromes and molecular switches or nonlinear optical materials. In spite of that, not much attention has been paid to the coordination chemistry of this class of versatile and polyfunctional heterocyclic ligands. This review intends to systematize the existing information in this field and to highlight some perspectives in the synthesis and applications of 1,3-thiazole, isothiazole and thiadiazole metal complexes.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com