Archives for Chemistry Experiments of Benzo[d]isothiazole

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Synthetic Route of 272-16-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Synthetic Route of 272-16-2, Name is Benzo[d]isothiazole, molecular formula is C7H5NS. In a Article, authors is Pedras, M. Soledade C.£¬once mentioned of Synthetic Route of 272-16-2

Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans

Potential inhibitors of Leptosphaeria maculans mediated detoxification of the phytoalexin brassilexin were designed and synthesized based on the planar heteroaromatic structure of isothiazolo[5,4-b]indole. Screening of these compounds for inhibition of brassilexin detoxification in cultures of L. maculans indicated that 4-(2-chlorophenyl)isothiazole had the largest effect on the rate of brassilexin detoxification. However, the most antifungal compound among the potential inhibitors, isothiazolo[5,4-b]quinoline, did not appear to affect the metabolism of brassilexin noticeably, suggesting that growth inhibition is not sufficient to slow down the rate of brassilexin detoxification. Furthermore, it was determined that 4-arylisothiazoles as well as isothiazolo[5,4-b]thianaphthene displayed antifungal activity against L. maculans.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com