New explortion of 6-Bromobenzo[d]isothiazole-3-carboxylic acid

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5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula (I)

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Some scientific research about 3,4-Dichloroisothiazole-5-carboxylic acid

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Use of Sulphur-Containing Heteroaromatic Acid Analogues as Bactericides

The present invention relates to the use of compounds according to formula (I) for controlling bacterial harmful organisms in useful plants. Moreover, the present invention relates to a method for controlling bacterial harmful organisms in useful plants by treating them with compounds according to formula (I).

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Simple exploration of Isothiazole

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Synthesis and investigations of the absorption spectra of hetarylazo disperse dyes derived from 2,4-quinolinediol

Synthesis of some novel hetarylazoquinoline dyes was achieved by diazotisation of nine heterocyclic amines using nitrosyl sulphuric acid, coupling with 2,4-quinolinediol. These dyes were characterized by UV-vis, FT-IR and 1H NMR spectroscopic techniques and elemental analysis. Visible absorption spectra of the dyes are discussed, both the effects of varying pH and solvent upon the absorption ability of azoquinolines. The colour of the dyes was discussed with respect to the nature of the heterocyclic ring and to the substituents therein. Temperature and concentration effects on the visible absorption maxima of the dyes are also reported.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Brief introduction of Benzo[d]isothiazole

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Characterization of Aroma Compounds in Two Meat Flavorings Prepared from Thermal Reaction of Enzymatic Hydrolysates of Black Pig and Common White Pig Meat Proteinss with Oxidized Lard

Meat flavorings were prepared by thermal reactions of enzymatic hydrolysates of black pig and common white pig (large white) meat proteins with oxidized lard. The volatile compounds of the two meat flavorings were analyzed by solvent assistant flavor distillation (SAFE) combined with gas chromatography and mass spectrometry (GC-MS). Based on retention indices and mass spectra, a total of 123 volatile compounds, including sulfur-containing compounds, nitrogencontaining heterocycles, oxygen-containing heterocycles, aldehydes, ketones, alcohols, acids, esters and hydrocarbons, were identified. In comparison, the white pig meat-derived flavoring had a greater percentage (relative to the total peak area) of alkyl furanes, aliphatic aldehydes and acids while the black pig meat-derived flavoring had a greater percentage of sulfur-containing compounds, nitrogen-containing heterocycles, and esters. However, their relative contents of ketones and alcohols were similar. Furthermore, by gas chromatography-olfactometry (GC-O), a total of 31 odor-active compounds were identified through comparison of their retention indices and odor characteristics with those of authentic standards. Among them, 28 compounds were common to two meat flavorings, and in particular dimethyltrisulfide, furfuryl mercaptan, 3-ethyl-2,5-dimethylpyrazine, 3-(methylthio) propanal,2-ethylthiophene,(E,E)-2,4-decadienal,(E)-2-decenal,(E)-2-nonenal,1-octen-3-ol and 3-hydroxy-2-butanone had high flavor dilution (FD) factors. However, the number of compounds with high FD values was greater in the black pig meat-derived flavoring than in the white pig meat-derived flavoring. Additionally, the spider-web plots for the potent odor-active compounds revealed that the black pig meat-derived flavoring had higher scores for meaty and fatty odors than the black pig meat-derived flavoring, which could explain why the black pig meat-derived flavoring had stronger meaty aroma than the black pig meat-derived flavoring.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

The Absolute Best Science Experiment for 272-16-2

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Synthesis, characterisation and application of disperse dyes derived from N-2-hydroxyethyl-l-naphthylamine

The synthesis and characterisation of a series of disperse dyes obtained by diazotisation of heterocyclic arylamines and coupling of these compounds with N-2-hydroxyethyl-1-naphthylamine are reported. The dyes were applied to cellulose acetate and their dyeing and fastness properties were assessed and summarised. The absorption spectra of the dyes are discussed, with regard to structure and substitution of the heterocyclic diazo component.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Awesome Chemistry Experiments For Isothiazole

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A vascular endothelial growth factor inhibitor injection of the pharmaceutical composition (by machine translation)

The invention belongs to the field of medicine, in particular to inhibit VEGF salts of the compound of formula I of injection drug composition, in pharmaceutical use and pharmaceutical formulations, particularly with respect to the tumor, the treatment of angiogenesis. The invention also relates to the method for synthesizing the compounds. (by machine translation)

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Can You Really Do Chemisty Experiments About 288-16-4

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14N Nuclear quadrupole coupling and methyl internal rotation in the microwave spectrum of 2-methylpyrrole

Using two molecular jet Fourier transform microwave spectrometers, the rotational spectrum of 2-methylpyrrole was recorded in the frequency range from 2 to 40 GHz. From the torsional splittings due to the internal rotation of the methyl group a barrier height of 279.7183(26) cm?1 was deduced. Because of the 14N nucleus, all lines show a quadrupole hyperfine structure. The microwave spectra were analysed using the XIAM and BELGI-Cs-hyperfine codes. The XIAM code enabled us to reproduce the whole data set with a root-mean-square deviation of 5.6 kHz while the BELGI-Cs-hyperfine code could provide a better root-mean-square almost by a factor of 2 compared to that of XIAM. The experimental results were complemented by quantum chemical calculations. The values of the methyl torsional barrier and the 14N nuclear quadrupole coupling constants are discussed and compared with other methyl substituted pyrroles as well as other aromatic five-membered rings.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

More research is needed about Isothiazole-4-carboxylic acid

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6,5-BICYCLIC OCTAHYDROPYRROLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to 6,5-bicyclic octahydropyrrolopyridine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

New explortion of Benzo[d]isothiazole

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Recent progress in the discovery and development of DNA gyrase B inhibitors

New antibacterials that modulate less explored targets are needed to fight the emerging bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search. These are both type II topoisomerases that can cleave both DNA strands, and can thus alter DNA topology during replication or similar processes. Currently, there are no ATP-competitive inhibitors of these two enzymes on the market, as the only aminocoumarin representative, novobiocin, was withdrawn due to safety concerns. The search for novel ATP-competitive inhibitors is a focus of ongoing industrial and academical research. This review summarizes the recent efforts in the design, synthesis and evaluation of GyrB/ParE inhibitors. The various approaches to achieve improved antibacterial activities are described, with particular reference to Gram-negative bacteria.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Extended knowledge of 288-16-4

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Imidazo[1,2-a]pyridines: Promising drug candidate for antitumor therapy

Imidazo[1,2-a]pyridine has been shown to be an important biologically active moiety. This review is a compilation of the scattered output of results of the anticancer activities of the imidazo[ 1,2-a]pyridine system since 2001, which have been classified as inhibition of CDK, VEGFR, PI3K, EGFR, RGGT etc. along with inhibition against different tumor cell lines. Various imidazo[ 1,2-a]pyridine based analogues have been used as lead molecules and are now under human clinical trials. This review will help the wider scientific community in the area of drug discovery of imidazo[1,2-a]pyridines as novel anticancer agents.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com