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Green synthesis, biological evaluation, and density functional theory calculations of thiazolidinone derivatives ? A review
Objective: Green chemistry articulates an area of research, developing from scientific discoveries about pollution awareness and it exploits a set of principles that reduces or eliminates the usage or generation of hazardous materials in all steps of synthetic progression. Hence, successful introduction of microwave technology is the current exhilarating field in green chemistry, generally classified as microwave-assisted organic synthesis of heterocyclic compounds exclusively thiazolidinone derivatives. Thiazolidinone nucleus especially the 4-thiazolidinone moiety has engaged a distinctive place in the field of medicinal chemistry due to widespread range of biological activities. This variety in the biological response profile has fascinated the consideration of many researchers to discover this skeleton to its manifold potential against numerous activities. This review is complementary to earlier reviews and aims to review the work reported on various biological activities of thiazolidinone derivatives from the year 1991 to the beginning of 2017. Statistics are presented for active compounds, some of which have passed the preclinical testing stage. Methods: An easy and efficient microwave-assisted protocol has been developed for the green synthesis of thiazolidinone derivatives, and reviewed their inhibitory effects on the activity of various pathogens and was optimized by density functional theory. Results: All compounds were found to possess various biological activities such as antibacterial, antitubercular, anticancer, antifungal and activities, respectively. Conclusion: These thiazolidinone derivatives can be believable as new candidates for the treatment of various diseases. Final thoughts attracted from this analysis can perform crucial function shaping the way our team believes concerning existing as well as future projects.
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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com