272-16-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 272-16-2, Name is Benzo[d]isothiazole,introducing its new discovery.
Design, synthesis and evaluation of phenethylaminoheterocycles as Kv1.5 inhibitors
Phenethylaminoheterocycles have been prepared and assayed for inhibition of the Kv1.5 potassium ion channel as a potential approach to the treatment of atrial fibrillation. A diverse set of heterocycles were identified as potent Kv1.5 inhibitors and were advanced to pharmacodynamic evaluation based on selectivity and pharmacokinetic profile. Heterocycle optimization and template modification lead to the identification of compound 24 which demonstrated increased atrial effective refractory period in the rabbit pharmacodynamic model with mild effects on blood pressure and heart rate.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 272-16-2, and how the biochemistry of the body works.272-16-2
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com