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Acid catalyzed nitrile thiolysis of 3-amino-acrylonitriles, toward the synthesis of 3,4-substituted-5-amino-isothiazoles
Application of an acid-catalyzed thioamidation of beta-amino-acrylonitriles to the corresponding beta-amino-thioacrylamides toward the synthesis of 3,4-substituted-5-amino-isothiazoles is described. The greatest yields were observed for examples with electron rich aromatic systems. This method uses inexpensive and easily handled reagents.
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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com