107869-45-4, An article , which mentions 107869-45-4, molecular formula is C10H15NO2S. The compound – (3aR,6S)-8,8-Dimethyl-4,5,6,7-tetrahydro-3H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide played an important role in people’s production and life.
Asymmetric synthesis of sultams and sulfonamides via diastereoselective reduction of N-sulfonylimines
The diastereoselective reduction of both cyclic and acyclic camphor sulfonylimines was investigated. With cyclic camphor sulfonylimines 1, reduction using NaBH4 in methanol afforded the corresponding camphorsultams 2 in 92-95% yield as single diastereomers with the exception of 1c where debromination occurred prior to reduction. For the large scale preparation of camphorsultam 1a and its derivatives, important chiral auxiliaries in asymmetric synthesis, reduction with NaBH4 is the reagent of choice. Reduction of acyclic camphor sulfonylimines 7 to camphorsulfonamides 8 with the bulky reducing reagent, LiAl(OBu-i)3H afforded the highest de’s (>90% de) and yields 90-95%.
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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com