Downstream synthetic route of Isothiazole-4-carboxylic acid

822-82-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,822-82-2 ,Isothiazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see

Name is Isothiazole-4-carboxylic acid, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 822-82-2, its synthesis route is as follows.

To a solution of l-[4-[propyl(tetrahydropyran-4-yl)amino]-5-oxido-6,7-dihydro- thieno[3,2-d]pyrimidin-5-ium-2-yl]azetidin-3-ol (5.0 mg, 14 muiotatauiotaomicronIota) in DCE (0.2 mL) was added solutions of 4-isothiazolecarboxylic acid (2.6 mg in 0.2 mL DCE, 20 muiotatauiotaomicronIota), DMAP (0.5 mg in 0.1 mL DCE, 4.1 muiotatauiotaomicronIota) and EDAC (3.9 mg in 0.2 mL DCE, 20 muiotatauiotaomicronIota). The mixture was shaken at room temperature overnight before it was concentrated in vacuo. Prep HPLC purification (basic) afforded the title compound as colorless oil. 1H NMR (DMSO-d6) delta: 9.81 (s, 1H), 9.00 (s, 1H), 5.49 (tt, J = 6.6, 3.9 Hz, 1H), 4.88 – 4.65 (m, 1H), 4.54 – 4.39 (m, 2H), 4.13 (dd, 2H), 3.96 (td, J = 11.3, 4.3 Hz, 2H), 3.54 – 3.35 (m, 5H), 3.25 – 3.16 (m, 1H), 3.07 – 2.97 (m, 2H), 1.95 – 1.82 (m, 2H), 1.74 (d, 1H), 1.65 – 1.54 (m, 3H), 0.90 (t, J = 7.3 Hz, 3H). HPLC-Retention time (XE Metode 7 CM) : 2.03 minutes. Detected “M + l”-mass: 478.15.

822-82-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,822-82-2 ,Isothiazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; LEO PHARMA A/S; LARSEN, Jens; (110 pag.)WO2019/57806; (2019); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com