Downstream synthetic route of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide

111248-89-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,111248-89-6 ,1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, other downstream synthetic routes, hurry up and to see

As a common heterocyclic compound, it belongs to isothiazole compound, name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, and cas is 111248-89-6, its synthesis route is as follows.

c. 1-Methyl-1,3-dihydrobenzo[c]isothiazole-2,2-dioxide To a suspension of 1,3-dihydrobenzo[c]isothiazole-2,2-dioxide (280 mg, 1.655 mmol) and potassium carbonate (229 mg, 1.66 mmol) in DMF (5 mL) was added iodomethane (414 muL, 6.62 mmol). The reaction was stirred for 6 h at rt and was then quenched with a sat. NH4Cl solution. The reaction mixture was concentrated and purified by column chromatography (CyHex/acetone) to afford the title compound as a white solid (270 mg, 89%).

111248-89-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,111248-89-6 ,1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com