Isothiazole-5-carboxylic acid, cas is 10271-85-9, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,10271-85-9
Step 1: N-methoxy-N-methylisothiazole-5-carboxamide To a solution of 5-isothiazole carboxylic acid (5 g, 38.7 mmol) in dichloromethane (200 mL), 4-(dimethylamino)pyridine (473 mg, 3.87 mmol), N,O-dimethylhydroxylamine hydrochloride (4.53 g, 46.4 mmol) (N-(3-dimethylaminopropyl)-N’-ethyl-carbodiimide hydrochloride (8.17 g, 42.6 mmol) and triethylamine (13.63 muL, 97.0 mmol) were added and the reaction was stirred overnight at room temperature. The reaction mixture was then successively washed with 1N HCl, 1N NaOH and brine. The organic layer was dried over MgSO4, filtered and concentrated under reduced pressure. The crude residue obtained was used as such for the next step. 1H NMR (400 MHz, acetone-d6): 8.59 (s, 1H), 7.97 (s, 1H), 3.94 (s, 3H), 3.38 (s, 3H).
10271-85-9 is used more and more widely, we look forward to future research findings about Isothiazole-5-carboxylic acid
Reference£º
Patent; Grimm, Erich L.; Ducharme, Yves; Frenette, Richard; Friesen, Richard; Gagnon, Marc; Juteau, Helene; Laliberte, Sebastien; MacKay, Bruce; Gareau, Yves; US2008/188521; (2008); A1;,
Isothiazole – Wikipedia
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