Name is 3-Piperazinobenzisothiazole hydrochloride, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 87691-88-1, its synthesis route is as follows.,87691-88-1
PREPARATION 7 6-r2- (4-Benzordlisothiazol-3-vl-piperazin-1-vl)-ethvll-2a, 3, 4, 5-tetrahydro-1 H- benzoRcdlindol-2-one; A 20 mL reaction vial was charged with 0.47 g (2 mmol, 1 eq) 6- (2-chloro- ethyl)-2a, 3,4, 5-tetrahydro-1 H-benzo [cd] indol-2-one, 0.51 g 3-piperazin-1-yl-benzo [d] – iso-thiazole hydrochloride, and 5 mL of 1 M aqueous sodium carbonate (Na2CO3) and heated to 100C for 60 h. The solid was filtered, washed with water and dried in vacuo overnight. The resulting solid was purified by medium pressure liquid chromatography (MPLC) (ethyl acetate (EtOAc) eluent) to give 0.36 g (43 % yield) of the desired material as a white solid. 1H NMR (400 MHz, CDCl3) 8 ppm 1.3 (qd, J=12. 3,3. 5 Hz, 1 H) 1.9 (m, 1 H) 2.2 (m, 1 H) 2.4 (dt, J=12. 2,4. 4 Hz, 1 H) 2.6 (m, 3 H) 2.8 (m, 6 H) 3.3 (dd, J=11. 8,5. 0 Hz, 1 H) 3.6 (s, 4 H) 6.6 (d, J=7. 6 Hz, 1 H) 7.0 (d, J=7. 8 Hz, 1 H) 7.3 (m, 1 H) 7.5 (m, 1 H) 7.8 (d, J=8. 1 Hz, 1 H) 7.9 (d, J=8.1 Hz, 1 H) 8.2 (s, 1 H). MS (APCI), (M+1) + = 292,419.
With the complex challenges of chemical substances, we look forward to future research findings about 3-Piperazinobenzisothiazole hydrochloride
Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/66165; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com