With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27148-03-4,Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide,as a common compound, the synthetic route is as follows.
It was obtained by addition of 4,4′-bipyridine (7.7 mg, 0.049 mmol) and thiosaccharine (20.3 mg, 0.102 mmol), to a dissolution of Zn(NO3)26H2O (15.2 mg, 0.0511 mmol) in water/ethanol 1:1, with mechanical stirring at ambient temperature. The resulting yellow precipitate was washed with water and dried. Yellow crystals, suitable for X-ray diffraction studies were obtained. Yield: 26.9%. Molar Conductivity (mS M1) = 138.7.Analytical percent composition calculated for C38H26N6O8S8Zn:C = 44.901%; H = 2.580%; N = 8.270%. Found: C = 45.996%; H =2.473%; N = 8.446%.Soluble in dimethyl sulfoxide and dimethyl formamide. Slightly soluble in water, ethanol, methanol and chloroform. Insoluble in acetone and dichloromethane. UV-Visible [DMSO, kmax nm]: 340.1H NMR (300 MHz, DMSO) d 8.98 (dd, 4H), 8.30 (dd, 4H), 7.87-8.02 (m, 4H), 7.73-7.81 (m, 4H), 7.35-7.72 (m, 10H). 13C NMR (75MHz, DMSO) d 191.56 (C1), 148.94 (C8), 145.88 (C10), 137.88 (C7),136.35 (C2), 132.28 (C4), 131.11 (C5), 125.16 (C3), 122.38 (C9),119.15 (C6).
27148-03-4, As the paragraph descriping shows that 27148-03-4 is playing an increasingly important role.
Reference£º
Article; Delgado, Fermin; Freire, Eleonora; Baggio, Ricardo; Gonzalez Pardo, Veronica; Dorn, Viviana; Dennehy, Mariana; Inorganica Chimica Acta; vol. 479; (2018); p. 266 – 274;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com