Name is Isothiazole-5-carboxylic acid, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 10271-85-9, its synthesis route is as follows.,10271-85-9
General procedure: The target compounds were synthesized using the procedure given in literature by refluxing aryl/heteroaryl acids with carbohydrazide 4a or 4b in phosphorous oxychloride. The reaction was monitored with the help of TLC to check its completion. After completion of reaction, the mixture was poured over crushed ice and allowed to precipitate. The precipitate was vacuum filtered, dried and recrystallized from methanol. Column chromatography was done on using n-hexane: ethylacetate mixture (7:3). Solvent was evaporated invacuo using rotary evaporator to obtain pure product.
With the complex challenges of chemical substances, we look forward to future research findings about Isothiazole-5-carboxylic acid
Reference£º
Article; Rane, Rajesh A.; Bangalore, Pavankumar; Borhade, Sheetal D.; Khandare, Preeti K.; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 49 – 58;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com