Day: November 3, 2020

Name is 3,4-Dichloroisothiazole-5-carboxylic acid, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 18480-53-0, its synthesis route is as follows.,18480-53-0

Add 5 mmol of compound I-1 to a 250 ml two-neck round bottom flask. 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) is 6 mmol, 1-hydroxybenzotriazole (HOBT) was 5.13 mmol, dissolved in dichloromethane solution and stirred in an ice bath for 15 minutes. A solution of the amine in dichloromethane (25 ml) was added to the reaction system. Then 6 mmol of Et3N was added and the reaction mixture was stirred at room temperature for 16 hours. After the reaction is completed, wash with water (2 ¡Á 60 ml) and saturated with brine (80 ml)Wash the organic layer, The organic layer was dried over MgSO4 and concentrated under reduced vacuo. The residue is purified by 100-200 mesh silica gel column chromatography to give compound II-1. The eluent is petroleum ether: ethyl acetate at 60-90 degrees Celsius.Its volume ratio is 4:1, yield 70%; white solid, melting point 125-126%,

With the complex challenges of chemical substances, we look forward to future research findings about 3,4-Dichloroisothiazole-5-carboxylic acid

Reference£º
Patent; Nankai University; Fan Zhijin; Yang Dongyan; Li Zhengming; Wang Haixia; Guo Xiaofeng; Zhang Nailou; Wu Qifan; Yu Bin; Zhou Shuang; (21 pag.)CN110041287; (2019); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is Isothiazole-5-carboxylic acid, and cas is 10271-85-9, its synthesis route is as follows.,10271-85-9

Example 318 (12 mg, 0.029 mmol), isothiazole-5-carboxylic acid (7.38 mg, 0.057 mmol) and triethylamine (7.97 mul, 0.057 mmol) were suspended in toluene (1 mL) in a pressure rated 1 dram vial. Diphenylphosphoryl azide (15.73 mg, 0.057 mmol) was added to the mixture which was heated to 110 C for 3 hours. The crude reaction mixture was purified by reverse phase HPLC (Method D, 65-100% 20 min, 100% 5 min) to yield Example 621 (1.3 mg, 2.38 mmol, 8% yield). C-MS: Method H, RT = 1.25 min, MS (ESI) m/z: 546.10 (M+H)+. 1HNMR (500 MHz, DMSO-d6) delta 8.77 (s, 1H), 8.62 (s, 1H), 8.21 (s, 1H), 8.02-8.12 (m, 1H), 7.88 (s, 1H), 6.81 (s, 1H), 4.61-4.69 (m, 2H), 4.46-4.56 (m, 2H), 4.10 (s, 3H), 3.19 (s, 3H).

With the complex challenges of chemical substances, we look forward to future research findings about 10271-85-9,belong isothiazole compound

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, cas is 111248-89-6, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,111248-89-6

4f. 5-bromo-1 ,3-dihydrobenzo[c]isothiazole 2,2-dioxide 1,3-Dihydro-benzo[c]isothiazole 22-dioxide (0.50 g, 3.14 mmol, 1.00 eq.)was solubilized in acetic acid (5 mL) at RT under nitrogen atmosphere.Bromine (0.45 g, 3.14 mmol, 1.00 eq.) in acetic acid (5 mL) was added dropwise over 5 minutes and the reaction mixture was stirred for 0.5 h. Potassium, acetate (0.28 g, 3.14 mmol, 1.00 eq.) was added and the reaction mixture was concentrated to dryness. The residue was taken in 2 % NaHCO3 solution and stirred for 10 minutes. This solution wasacidified to pH 2 using conc. HCI (2.5 mL) and extracted with MTBE (50 mL). The MTBE layer was washed with water (50 mL), brine solution (25 mL), dried over Na2SO4 and concentrated to get the crude product as brown solid. The crude product was triturated with petroleum ether (10 mL), filtered to a light brown solid (HPLC purity app. 86 %) which was further purified by column chromatography using 60-1 20 mesh silica gel, 15 %ethyl acetate in petroleum ether as eluent to get a yellow solid (HPLC purity app.90 %). The resulting product was then triturated with ethanol (5 mL), filtered and dried to get the title compounds as light yellow solid (0.35 g, 47.7 %, 94% purity).

111248-89-6 is used more and more widely, we look forward to future research findings about 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide, and cas is 27148-03-4, its synthesis route is as follows.,27148-03-4

A solution of Htsac (0.035 g, 0.18 mmol) in MeOH was added toa solution of 1 (0.10 g, 0.18 mmol) in CHCl3 (10 cm3). The mixturewas stirred for 2 h and the resulting pale brown solid was collectedand dried in vacuum. Yield 0.116 g, 90%. Anal. Calc. for C25H28ClN3-O2Pd2S2: C, 42.0, H, 4.0, N, 5.9. Found: C, 42.2, H, 4.0, N, 5.7. Molarconductivity (DMSO): 0.30 (X-1 mol1 cm1). IR: 3083w, 2916w,1558 m, 1453vs, 1317 s, 1168 s, 1020 s, 815 s, 449w, 362 s cm1.1H NMR (DMSO d6): d 8.12-8.10 (dd, J 7.2, 1.2 2H, Ph), 7.97-7.95(m, 1H, Ph), 7.84-7.82 (m, 2H, Ph), 7.60 (d, J 7.2, 1H, Ph), 7.47 (d, J 7.2, 1H, Ph), 7.05-6.91 (m, 5H, Ph), 6.82 (d, J 7.2, 1H, Ph), 4.02(s, 4H, CH2), 2.72 (s, 12H, 4CH3). Mp: 202-204 C.

With the complex challenges of chemical substances, we look forward to future research findings about 27148-03-4,belong isothiazole compound

Reference£º
Article; Al-Jibori, Subhi A.; Hameed, Wisam J.; Al-Janabi, Ahmed S.; Basak-Modi, Sucharita; Wagner, Christoph; Hogarth, Graeme; Inorganica Chimica Acta; vol. 479; (2018); p. 197 – 202;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

111248-89-6, 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 1,3-dihydro-2,1-benzisothiazoline 2,2-dioxide (Chiarino et al, J. Heterocycl. Chem. 23(6), 1645-9, 1986) (0.74 g, 4.4 mmol) in anhydrous dichloromethane (minimum amount) at room temperature was added sequentially N,N-diisopropylethylamine (0.76 mL, 4.4 mmol) and 2-(trimethylsilyl)ethoxymethyl chloride (0.77 mL, 4.4 mmol). After 30 min, the reaction was poured into water (50 mL), the layers were separated, and the aqueous phase was extracted with ethyl acetate (2*50 mL). The organic layers were combined, washed with brine (30 mL), dried over magnesium sulfate, filtered and concentrated in vacuo to give 1, 3-dihydro-I-(2′-trimethylsilylethyl)-2, 1-benzisothiazoline 2,2-dioxide (1.3 g, 99%) as an off-white solid. 1H NMR (CDCl3, 300 MHz) delta0.02 (s, 9 H), 0.97 (dd, 2 H, J=8.3, 8.2 Hz), 3.73 (dd, 2 H, J=8.2, 8.3 Hz), 4.40 (s, 2 H), 5.08 (s, 2 H), 7.05 (d, 1 H, J=7.4 Hz), 7.07 (dd, 1 H), 7.26 (d, 1 H, J=7.4 Hz), 7.35 (‘t’, 1H, J=7.6, 7.6 Hz). MS ((+) APCI m/z 317 [M+NH4]+.

111248-89-6, As the paragraph descriping shows that 111248-89-6 is playing an increasingly important role.

Reference£º
Patent; American Home Products Corporation; Ligand Pharmaceuticals, Inc.; US6339098; (2002); B1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3,4-Dichloroisothiazole-5-carboxylic acid, and cas is 18480-53-0, its synthesis route is as follows.,18480-53-0

SYNTHESIS EXAMPLE 2 Process (a): After thionyl chloride (10 ml) had been added to 3,4-dichloro-5-isothiazole-carboxylic acid (1.28 g), the mixture was refluxed by heating for 2 hours. The excess of thionylchloride was then distilled off under reduced pressure, and 3,4-dichloro-5-isothiazolecarboxylic acid chloride was obtained.

With the rapid development of chemical substances, we look forward to future research findings about 3,4-Dichloroisothiazole-5-carboxylic acid

Reference£º
Patent; Assmann, Lutz; Kitagawa, Yoshinori; Ishikawa, Koichi; Yamazaki, Daiei; Sawada, Haruko; Araki, Yasuo; Sakuma, Haruhiko; Kinbara, Taro; Imanishi, Kinya; US2003/13750; (2003); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

Name is 3-Chlorobenzo[d]isothiazole, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 7716-66-7, its synthesis route is as follows.,7716-66-7

Ethylenediamine (45 mL) was heated to 80 0C. A room temperature solution of 3-chlorobenzo[d]isothiazole (12g, 70.7 mmol) in ethylenediamine (5 mL) was added to the heated ethylenediamine dropwise. The resulting solution was heated at 80 0C for 3 h. The reaction mixture was cooled to room temperature and water (75 mL) was added. The aqueous mixture was extracted with ethyl acetate twice and the ethyl acetate layers were separated. The combined organic layers were dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure to yield N1-(benzo[d]isothiazol-3-yl)ethane-l,2-diamine as a light yellow solid (8 g). 1H-NMR (300 MHz, CDCl3): 7.79-7.64 (m, 2H), 7.52 (t, IH), 7.34 (t, IH), 5.60 (broad s, IH), 3.62 (t, 2H), 3.08 ppm (t, 2H).

With the complex challenges of chemical substances, we look forward to future research findings about 3-Chlorobenzo[d]isothiazole

Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; WO2006/91858; (2006); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,87691-88-1

The above intermediate IV (0.01 mol) and the hydrochloride salt of the piperazine compound (V) (0.01 mol) were dissolved in DMF (100 mL), and K2CO3 (0.02 mol) was added.According to the general operation three,Preparation of 3-(3-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)propyl)-1H-indole-5-hydroxy(VI-10) hydrochloride 3.21g, yield 75%

With the rapid development of chemical substances, we look forward to future research findings about 3-Piperazinobenzisothiazole hydrochloride

Reference£º
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Gu Zhengsong; Zhou Ainan; Xiao Ying; (26 pag.)CN109467554; (2019); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

4-Bromoisothiazole, cas is 24340-77-0, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,24340-77-0

General procedure: 2 wt% DL-alpha-Tocopherolmethoxypolyeneglycol succinate solution (1.5 mL) was added to a mixture of 5-methoxycarbonylbenzofuran-2-MIDA boronate (200 mg, 0.604 mmol), (dtbpf)PdCl2 (32 mg, 0.048 mmol) and bromobenzene (95 mg, 0.604 mmol) under N2. Et3N (0.25 mL, 1.81 mmol) was added to thesuspension under N2. The reaction mixture was vigorously stirred at 40 C for 22 h under N2. Theresulting mixture was diluted with water to form a precipitate, which was filtered, washed with water anddissolved with CHCl3. The obtained organic solutions were dried over Na2SO4 and concentrated. Theresidue was purified by flash chromatography (SiO2, AcOEt : hexane = 30 : 70) to give 143.0 mg (94%)of white powde;

With the rapid development of chemical substances, we look forward to future research findings about 4-Bromoisothiazole

Reference£º
Article; Sakurai, Yohji; Heterocycles; vol. 94; 7; (2017); p. 1322 – 1336;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

Name is 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 936-16-3, its synthesis route is as follows.,936-16-3

A mixture of C105 (80 mg, 0.16 mmol), C113 (39.3 mg, 0.232 mmol), cesium carbonate (114 mg, 0.350 mmol), and potassium iodide (28.9 mg, 0.174 mmol) in /V,/V-dimethylformamide (2 mL) was stirred at 80 ¡ãC for 16 hours. The reaction mixture was then diluted with ethyl acetate (30 mL), washed with saturated aqueous sodium chloride solution (3 x 30 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Preparative thin layer chromatography on silica gel (Eluent: 1 :3 ethyl acetate / petroleum ether) provided the product as a light yellow oil. Yield: 55 mg, 94 muetaiotaomicronIota, 59percent. LCMS m/z 607.0 [M+Na+].

With the complex challenges of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide

Reference£º
Patent; PFIZER INC.; BECK, Elizabeth Mary; BRODNEY, Michael Aaron; BUTLER, Christopher Ryan; GILBERT, Adam Matthew; HELAL, Christopher John; JOHNSON, Douglas Scott; MCALLISTER, Laura Ann; MONTGOMERY, Justin Ian; O’NEIL, Steven Victor; ROGERS, Bruce Nelsen; VERHOEST, Patrick Robert; WEBB, Damien; (236 pag.)WO2017/21805; (2017); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com