2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, cas is 936-16-3, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,936-16-3
2-Chloro-4-(4-Boc-piperazin-l-yl)quinazoline (140 mg, 0.40 mmol), 253-dihydro-l,2- benzisothiazole l5l-dioxide (85 mg, 0.50 mmol) and potassium carbonate (110 mg, 0.80 mmol) in DMSO (2 ml) were heated at 90¡ã for 16 h and then at 110¡ã for 5 h. The reaction mixture was diluted with brine and extracted with dichloromethane (x3). The combined o organic phases were dried (MgSO4) and evaporated to dryness. The residue was dissolved in dichloromethane (2 ml) and TFA (0.5 ml) was added. The reaction mixture was stirred at ambient temperature for 16 h. The solvent was evaporated and the crude was purified by preparative HPLC to give the acetate of the title compound (71 mg, 40percent). 1H NMR (400 MHz, DMSO-J6) d ppm 7.90 – 8.02 (2 H, m) 7.61 – 7.84 (5 H, m) 7.33 – 7.41 (1 H3 m) 5.19 (2 H, s) 3.79 – 3.88 (4 H, m) 2.87 – 2.95 (4 H, m); ESI-MS m/z M+H+ 382.
936-16-3 is used more and more widely, we look forward to future research findings about 2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide
Reference£º
Patent; ASTRAZENECA AB; WO2007/108744; (2007); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com