Analyzing the synthesis route of 677304-75-5

With the synthetic route has been constantly updated, we look forward to future research findings about 6-Bromobenzo[d]isothiazole-3-carboxylic acid,belong isothiazole compound

As a common heterocyclic compound, it belong isothiazole compound,6-Bromobenzo[d]isothiazole-3-carboxylic acid,677304-75-5,Molecular formula: C8H4BrNO2S,mainly used in chemical industry, its synthesis route is as follows.,677304-75-5

Preparation 45; 6-(4-Hvdroxy-2-methyl-phenyl)-benzordlisothiazole-3-carboxylic acid; To a degassed solution of 6-Bromo-benzo[d]isothiazole-3-carboxylic acid (0.42g, 1.54mmol), 3-Methyl-4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl-phenol (0.54, 2.3 lmmol), 2-Dicyclohexylphosphino-2′,6′-dimethoxy- 1 , 1 ‘-biphenyl (0.064g, 0.154mmol), and potassium phosphate (0.7 Ig, 3. lmmol) in dioxane (8mL) and water (4mL) is added Pd(OAc)2 (6.5mg, 0.03mmol). The reaction is degassed again and heated to 80 degrees for 18 h. The reaction is cooled to room temperature and concentrated under reduced pressure. The material is diluted with EtOAc and IN HCl. The layers are separated and concentrated under reduced pressure. The crude material is diluted with 20 mL of MeOH and 2 mL H2SO4 and heated to reflux for 2 h. The reaction is concentrated onto silica and purified using a gradient of 20 to 50% EtOAc in Hexanes to yield the title compound (0.12g, 26% yield). ES/MS m/e 300.0 (M+l).

With the synthetic route has been constantly updated, we look forward to future research findings about 6-Bromobenzo[d]isothiazole-3-carboxylic acid,belong isothiazole compound

Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/140174; (2007); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com