The important role of 677304-75-5

With the complex challenges of chemical substances, we look forward to future research findings about 6-Bromobenzo[d]isothiazole-3-carboxylic acid

Name is 6-Bromobenzo[d]isothiazole-3-carboxylic acid, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 677304-75-5, its synthesis route is as follows.,677304-75-5

The following procedure was used to prepare benzisothiazole fer/-butyl esters:Di-ferz’-butyldicarbonate (128 mmol) was added to a suspension of 6-bromo-l,2- benzisothiazole-3-carboxyIic acid (46.5 mmol) and 4-dimethylaminopyridine (4.26 mmol) in tert-buty alcohol (40.0 mL) and tetrahydrofuran (40.0 mL) and the reaction mixture was heated at 65 0C for 16 hours. There was vigorous carbon dioxide evolution which gradually subsided as the mixture become homogeneous. The reaction mixture was concentrated and the residue was dissolved in dichloromethane. The dichloromethane solution was filtered through silica gel (ca. 5Og) and the eluent was concentrated to provide the ester product in 99% yield.The following ester was prepared using this method:tert-Butyl S-brorno-l^-benzisothiazole-S-carboxylate. tert-Butyl -bromo-l^-benzisothiazole-S-carboxylate.

With the complex challenges of chemical substances, we look forward to future research findings about 6-Bromobenzo[d]isothiazole-3-carboxylic acid

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2007/56582; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com