As a common heterocyclic compound, it belong isothiazole compound,3-Piperazinobenzisothiazole hydrochloride,87691-88-1,Molecular formula: C11H14ClN3S,mainly used in chemical industry, its synthesis route is as follows.,87691-88-1
[0070] 5) To the product of step 4) were added 3-(1 -piperazinyl)-1,2-benzisothiazole hydrochloride, anhydrous potassium carbonate, potassium iodide and acetonitrile, and the mixture was heated under reflux for 24 hours, and then cooled to room temperature and filtrated. The solvent was distilled to give yellowish oil, which was passed through a column to give white solid.10071] ?H NMR (CDC13) oe 2.11-2.14 (m, 2H), 2.64 (t, 2H, J=13.6 Hz), 2.72-2.74 (m, 4H), 3.40 (t, 2H, J=14 Hz), 3.58- 3.60 (m, 4H), 7.33-7.37 (m, 1H), 7.44-7.52 (m, 4H), 7.80 (d, 1H, J=8 Hz), 7.89 (d, 1H, J=8.4 Hz), 7.99 (d, 1H, J=2 Hz)10072] MS (ESI) m/z 438.2 ([M+H]+.
With the synthetic route has been constantly updated, we look forward to future research findings about 3-Piperazinobenzisothiazole hydrochloride,belong isothiazole compound
Reference£º
Patent; HUAZHONG UNIVERSITY OF SCIENCE & TECHNOLOGY NHWA PHARMA CORPORATION; Zhang, Guisen; Chen, Yin; Xu, Xiangqing; Liu, Bifeng; Feng, Xiaojun; Zhao, Song; Liu, Shicheng; Yu, Minquan; Lan, Yu; Qiu, Yinli; US2014/24656; (2014); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com