3-Chlorobenzo[d]isothiazole, cas is 7716-66-7, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,7716-66-7
A mixture of 508.2 g of piperazine, 200 ml of tertiary butanol and 200 g of 3-chloro-1,2-benzisithiazole was refluxed for 15 hours. The reaction mass was quenched with 800 ml of water and filtered through a Hyflow (flux calcined diatomaceous earth) bed to make it particle-free. The pH of the reaction mass was adjusted to 13 with 50percent aqueous NaOH and then the reaction mass was extracted three times with 1200 ml volumes of toluene. The combined organic layers were washed with 200 ml of water, treated with 10 g of carbon, and the carbon was removed by filtration. The solvent was distilled until about 1000 ml remained, under reduced pressure at a temperature below 65¡ã C. The reaction mass was cooled to 0-5¡ã C. and stirred for 80 minutes. The formed solid was filtered and washed with 20 ml of toluene to yield 148.3 g of the title compound.
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Reference£º
Patent; Venkataraman, Sundaram; Rao, Uppala Venkata Bhaskara; Muvva, Venkateswarlu; Chitta, Vijayawardhan; US2006/89502; (2006); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com