As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO183,mainly used in chemical industry, its synthesis route is as follows.,7716-66-7
Preparation 1 SYNTHESIS OF 3-PIPERAZIN-1-YLBENZO[D]ISOTHIAZOLE A mixture of anhydrous piperazine (2.75 g, 32 mmol) and 3-chlorobenzo[d]isothiazole (1.00 g, 5.80 mmol) were heated in a sealed tube in an oil bath at 125¡ã C. for 24 hours. The orange melt was then quenched with ice water and 50percent NaOH was added in one portion. The mixture was extracted with dichloromethane to get the crude product which was purified by recrystallization to afford the title compound as a pale yellow solid in 24percent yield (0.260 g). MS (ES+) m/z 220 (M+1).
With the complex challenges of chemical substances, we look forward to future research findings about 3-Chlorobenzo[d]isothiazole,belong isothiazole compound
Reference£º
Patent; XENON PHARMACEUTICALS INC.; US2008/125434; (2008); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com