3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,87691-88-1
A mixture of 8 (700 mg, 2.2 mmol), 9 (817 mg, 3.2 mmol), Nal (651 mg, 4.3 mmol), and triethylamine (1.5 mL, 10.9 mmol) in acetonitrile (50.0 mL), was heated to reflux for 48 h, and allowed to cool. The mixture was concentrated to dryness in vacuo. The residue was suspended in water (50 mL) and sonicated for 5 min, and then filtered through a sintered glass frit. The solid was rinsed with additional water, dried under vacuum, and purified by chromatography (silica gel, gradient 3 – 5 % MeOH in CH2CI2) to provide compound 10 (630 mg, 63 %) as a white solid. 1H NMR (400 MHz, CDCl3): delta 10.75 (br s, 1H), 7.93 (d, 1H), 7.80 (d, 1H), 7.50-7.43 (m, 1H), 7.40-7.35 (m, 1H), 7.29-7.22 (m, 1H), 7.10 (d, 1H), 6.98 (s, 1H), 4.10 (t, 2H), 3.61-3.52 (m, 4H), 3.15 (t, 2H), 3.00 (t, 2H), 2.80-2.72 (m, 4H), 2.70 (t, 2H), 2.29-2.20 (m, 2H), 2.10-2.02 (m, 2H), MS m/z 460.97 [C26H28N4O2S + H]+
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Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/26864; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com