822-82-2,822-82-2, Isothiazole-4-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of the compound of Preparation 141 (1.4 g, 11.0 mmol) in tetrahydrofuran (6 ml), at -5 C., was added dropwise borane (1M in tetrahydrofuran, 16.5 ml). The reaction mixture was allowed to warm to room temperature and stirred for 18 h. The mixture was quenched by addition of water: acetic acid (1:1, 4 ml) and the mixture was concentrated in vacuo. The residue was added to saturated aqueous sodium hydrogen carbonate solution (5.5 ml) at 0 C. and the two layers were separated. The aqueous layer was extracted with ethyl acetate (750 ml) and the combined extracts were concentrated in vacuo to give the title compound (700 mg). 1H-NMR (CDCl3): 4.80-4.84 (2H), 8.69-8.71 (1H), 8.76-8.78 (1H)
The synthetic route of 822-82-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER LIMITED; US2008/103130; (2008); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com