2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide, cas is 936-16-3, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,936-16-3
Example 85 2-[{1-(4-Fluorophenyl)-5-isobutyl-1H-pyrazol-3-yl}methyl]-2,3-dihydro[d]isothiazole 1,1-dioxide (Compound 30) To a solution of 1,2-benzisothiazoline-1,1-dioxide (97.1 mg, 0.574 mmol) in N,N-dimethylformamide (3 mL) was added potassium carbonate (793 mg, 5.74 mmol) at room temperature, followed by stirring for 10 min. The solution was slowly added with drops of methylene chloride (5 mL) in {1-(4-fluorophenyl)-5-isobutyl-1H-pyrazol-3-yl}methyl bromide (199 mg, 0.638 mmol), and stirred for a day at room temperature. When the reaction was completed as measured by TLC (Hexane:EtOAc=3:1), the reaction mixture was filtered through celite. The filtrate was neutralized with 1M HCl and an aqueous saturate sodium hydrogen carbonate solution. After extraction with ethyl acetate and water, the organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo. The concentrate was purified by column chromatography (Hexane:EtOAc=6:1) to afford the title compound (124 mg, 79percent, white solid). M.P. 119.3-122.7¡ã C.; 1H NMR (300 MHz, CDCl3) delta 7.83-7.49 (m, 3H), 7.41-7.34 (m, 3H), 7.20-7.14 (m, 2H), 6.35 (s, 1H), 4.52 (s, 2H), 4.39 (s, 2H), 2.46 (d, J=7.2 Hz, 2H), 1.87-1.73 (m, 1H), 0.84 (d, J=6.6 Hz, 6H); 13C NMR (75 MHz, CDCl3) delta 163.7, 160.4, 147.4, 144.8, 135.9, 135.1, 134.0, 132.7, 129.1, 127.7, 127.6, 124.6, 121.3, 116.2, 115.9, 106.1, 53.5, 50.0, 41.3, 35.1, 28.3, 22.4
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Reference£º
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; NAM, Ghil Soo; CHOI, Kyung Il; KIM, Jung Hyun; PAE, Ae Nim; HONG, Jin Ri; LEE, Jae Kyun; (30 pag.)US2015/329533; (2015); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com