With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76857-14-2,Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
76857-14-2, To the reaction solution B, 2000 ml of a saturated sodium hydrogencarbonate solution was added, and the mixture was stirred, and the phases were separated. The aqueous phase was taken and the temperature was lowered to 5 C or lower. To the solution was added 60 g / 400 ml of 4-carboxy-3-hydroxy-5-mercaptoisothiazolium trisodium (CHMT) aqueous solution. The pH of the reaction solution is controlled to be 6.0 to 9.0, the content of the cefotetan tautomer is less than or equal to 6.0%, the pH is adjusted to 6.5, 50g of active alumina is added, stirred for 1 hour, filtered, hydrochloric acid to adjust the pH of the filtrate is 1.5 to 2.5, filtration, in the original cefotetan acid.
As the paragraph descriping shows that 76857-14-2 is playing an increasingly important role.
Reference£º
Patent; Shenzhen Salubris Pharmaceuticals Co., Ltd.; Lei, Jiangang; Liang, Guilin; Yang, Siyuan; Zhao, Li; (11 pag.)CN103724359; (2016); B;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com