The isothiazole compound, cas is 27148-03-4 name is Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide, mainly used in chemical industry, its synthesis route is as follows.,27148-03-4
Step A: Methyl 2-[(1,1-dioxo-1,2-benzoisothiazol-3-yl)thio]-3-(4-benzyloxyphenyl)propionate The solution of 0.3 g (0.001 mol) of methyl 3-[4-(benzyloxy)phenyl]-2-chloropropionate in methanol (2 ml) was added dropwise to the solution of 0.2 g (0.001 mol) 1,1-dioxo-1,2-benzoisothiazol-3(2H)-thione (thiosaccharine) and 0.04 g (0.001 mol) NaOH in methanol (3 ml). The solution thus obtained was heated at reflux for 5 h. The crude product obtained after evaporating the solvent was used without purification in the next step of the synthesis.
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Reference£º
Patent; ADAMED, Sp. z.o.o.; US2006/160870; (2006); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com