27148-03-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27148-03-4,Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide,as a common compound, the synthetic route is as follows.
A solution of tsac (0.051 g, 0.26 mmol) in MeOH (5 cm3)was added to a solution of 1 (0.051 g, 0.13 mmol) inMeOH (10 cm3). The mixture was stirred at 30 C for 2 h.The yellow-orange solid formed was collected by filtrationand dried under vacuum. Yield 0.068 g, 75%. Anal. Calc.for C28H26N4O4PdS4: C, 46.9, H, 3.7, N, 7.8. Found: C,46.9, H, 3.8, N, 8.0. Molar conductivity (DMSO): 0.40(X-1 mol-1 cm-1). IR (KBr): 3425sb, 3051w, 2922w,1541m, 1463m, 1384s, 1163s, 1004m, 806m, 370s cm-1.1H NMR (DMSO-d6): d 7.89 (dd, J 8.0, J 3.2, 4H, tsac),7.71 (t, J 8.0, 2H, tsac), 7.58 (t, J 8.0, 2H, tsac), 7.29 (s,10H, Ph), 4.58 (bs, 4H, 2NH2), 3.69 (s, 4H, 2CH2) ppm.
27148-03-4,Benzo[d]isothiazole-3(2H)-thione 1,1-dioxidebelongs to isothiazole compound, is more and more widely used in various fields. and we look forward to future research findings.
Reference£º
Article; Al-Jibori, Subhi A.; Hameed, Wisam J.; Al-Hayaly, Lamaan J.; Wagner, Christoph; Hogarth, Graeme; Transition Metal Chemistry; vol. 42; 1; (2017); p. 79 – 84;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com