With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.822-82-2,Isothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
822-82-2, solution of 1 ,2-thiazole-4-carboxylic acid (36 mg, 0.28 mmol) and HATU (105 mg, 0,28 mmol) in DMA (1 mL) was added to a mixture of N-{4-[4-oxo-3-(phenylamino)-4,5,6,7- tetrahydro-1 H-pyrrolo[2,3-c]pyridin-2-yl]pyridin-2-yl}acetamide (24; 50 mg, 0.14 mmol) and DIPEA (48 pL, 0.28 mmol) in DMA (1 mL) and stirred for 16 h at 50X. The mixture was concentrated and purified by preparative HPLC (basic method) to give the title compound (37 mg, 54%). 1H-NMR (400 MHz, DMSO-d6), delta [ppm]= 2.08 (3H), 4.14+4.34 (2H), 4.90+5.08 (2H), 6.58 (2H), 6.60 (1 H), 7.03 (2H), 7.21 (1 H), 7.45 (1 H), 8.13 (1 H), 8.23+8.29 (1 H), 8.71 +8.80 (1 H), 9.35+9.45 (1 H), 10.41 (1 H), 12.07+12.36 (1 H)
822-82-2 Isothiazole-4-carboxylic acid 12430656, aisothiazole compound, is more and more widely used in various.
Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; GRAHAM, Keith; KLAR, Ulrich; BRIEM, Hans; SIEMEISTER, Gerhard; MOeNNING, Ursula; VON NUSSBAUM, Franz; (332 pag.)WO2017/102649; (2017); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com