4576-90-3, Isothiazole-3-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution compound 40 (3 g, 23.25 mmol) in CH2Cl2 (60 mL) under inert atmosphere were added EDCI.HCl (4.9 g, 25.58 mmol), DMAP (2.8 g, 23.25 mmol), N- methylmorpholine (7.65 mL, 69.76 mmol) and N, O-dimethylhydroxylamine hydrochloride (2.72 g, 27.90 mmol) at 0 oC, followed by warming to room temperature and stirring for 16 h. The reaction was monitored by TLC. After completion of the reaction, the reaction mixture was diluted with ice-cold water and extracted with CH2Cl2. The combined organic extracts were dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to obtain the crude. The crude was purified through silica gel flash column chromatography using 40-45% EtOAc/ hexanes to afford compound 41 (2.5 g, 63%) as brown syrup. TLC: 40% EtOAc/ hexanes (Rf: 0.5); 1H NMR (400 MHz, DMSO-d6): delta 9.15 (d, J = 4.8 Hz, 1H), 7.63 (d, J = 4.4 Hz, 1H), 3.69 (s, 3H), 3.33 (s, 3H); LCMS Calculated for C6H7NOS: 141.02; Observed: 142.0 (M+1)+.LC-MS: 98.67%; 172.9 (M+1)+.
The synthetic route of 4576-90-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASSEMBLY BIOSCIENCES, INC.; TURNER, William, W., Jr.; LI, Leping; HAYDAR, Simon, Nicolas; BURES, Mark, G.; RAI, Roopa; FRANCIS, Samson; ARNOLD, Lee, Daniel; (0 pag.)WO2018/160878; (2018); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com