10271-85-9, Isothiazole-5-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 5-isothiazolecarboxylic acid (500 mg, 3.87 mmol, commercially available from e.g. Fluorochem or Astatech) in dry Dichloromethane (DCM) (12.9 ml) was stirred at room temperature under an atmosphere of argon. EDC (891 mg, 4.65 mmol) and HOBt (296 mg, 1.936 mmol) were added to the stirred solution. The resulting solution was stirred at room temperature under an atmosphere of argon for 1/2 hour. After this time, 1 ,1-dimethylethyl hydrazinecarboxylate (614 mg, 4.65 mmol) was added and the solution was stirred for a further 18 hours at room temperature (overnight). The solution was diluted with DCM (approx 30 ml) and washed with water (2 x 20ml). The organics were dried over MgSO4, filtered and concentrated under reduced pressure to give a brown coloured oil. The oil was chromatographed [Sitheta2, EtOAc/Hexane 0-100%] to give a thick, yellow-coloured oil which solidified on standing to afford the product in 480 mg. The residue was used directly in the next step. LCMS [M+H]+ 244.14 (at) 0.66 min (2 min run).
As the paragraph descriping shows that 10271-85-9 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com