With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.936-16-3,2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide,as a common compound, the synthetic route is as follows.
Step 2. A mixture of 23 (180 mg, 0.70 mmol), 1 (60 mg, 0.35 mmol), CsF (107 mg, 0.70 mmol), Cs2CO3 (458 mg, 1.41 mmol) in DMF (3 mL) was degassed and purged with N2 (3X). The mixture was stirred at 80¡ãC for 1 h, filtered, and then purified by prep-HPLC to give Compound 143 (15 mg, 5percent) as a light yellow solid. 1H NMR (DMSO-d6, 400MHz) delta 7.97 (d, 1H), 7.81 (s, 1H), 7.72 (d, 1H), 7.43 (s, 1H), 7.31 (s, 2H), 7.18 (s, 2H), 5.09 (s, 2H), 2.33 (s, 3H); LCMS (ESI): m/z 356.0 (M+H).
The synthetic route of 936-16-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NUMERATE, INC.; RAIMUNDO, Brian; KOLTUN, Elena S.; GRIFFIN, John; STANGELAND, Eric; (93 pag.)WO2018/49324; (2018); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com