7716-66-7, 3-Chlorobenzo[d]isothiazole is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3-Chlorobenzo[d]isothia-zole (300 mg, 3.0 mmol) was dissolved in propane- 1,3 -diamine (3 mL) and heated at 8O0C for 3 h. The reaction mixture was cooled to room temperature, poured into water and extracted with ethyl acetate. The organic extract was dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure to yield ^-(benzotdJisothiazol-S-ytypropane- 1,3-diamine as a yellow solid, (530 mg). 1H NMR (300 MHz, CDCl3): 7.8 (m, IH), 7.7 (m, IH), 7.5 (m, 2H), 7.3 (m, IH), 3.7 (m, 2H), 2.9 (t, 2H), 1.9 ppm (m, 2H).
The synthetic route of 7716-66-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; WO2006/91858; (2006); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com