With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87691-88-1,3-Piperazinobenzisothiazole hydrochloride,as a common compound, the synthetic route is as follows.
2. Preparation of ZPR in glycerol In a three necked flask was charged BITP HC1 (25g, 0. 098 mol), glycerol (62 ml), Na2C03 (13g) and the mixture was stirred for 10 minutes. CEI (5.9g) was added and the reaction mixture was heated for 3h at 115-120C. After 3h, the reaction was almost complete; after cooling to room temperature the solid was filtrated and was triturated in water and dried. The dried solid weights 42 g and the purity was 89.03%.
The synthetic route of 87691-88-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/40160; (2005); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com