Synthesis and synthesis-based structural elucidation of (-)-macrosphelides J and K was written by An, Hongchan;Kim, Seung-Hee;Kim, Heegyu;Kim, Kyeojin;Sim, Jaehoon;Jang, Jaebong;Paek, Seung-Mann;Suh, Young-Ger;Yun, Hwayoung. And the article was included in Heterocycles in 2015.Synthetic Route of C13H19NO3S This article mentions the following:
The structures of (-)-macrosphelides J (I) and K (II) have been elucidated via asym. total syntheses. Key points of the structure elucidation include an initial prediction of the stereochemistries of (-)-macrosphelides J and K based on the structural relationship of the macrosphelides and mol. modeling of macrosphelide B. Our synthetic approach features an isoxazoline-based route involving a diastereoselective olefin-nitrile oxide cycloaddition, an intricate reductive N-O bond cleavage of an isoxazoline and O-alkylation of the labile β-hydroxy ketone intermediate. In the experiment, the researchers used many compounds, for example, 1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7Synthetic Route of C13H19NO3S).
1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. Isothiazoles are readily prepared from isoxazoles. Thus, reductive ring opening of isoxazoles gives enaminones , which on treatment with phosphorus pentasulfide and chloranil give the corresponding isothiazoles.Synthetic Route of C13H19NO3S
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com